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Clinical outcomes, drug toxicity and emergence of ceftazidime-avibactam resistance among patients treated for carbapenem-resistant Enterobacteriaceae infections

  1. M. Hong Nguyen1,2,3
  1. 1Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
  2. 2Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
  3. 3XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
  4. 4Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh Pennsylvania
  5. 5VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania
  6. 6Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey
  1. Corresponding Author: Cornelius J. Clancy, MD, Associate Professor of Medicine, University of Pittsburgh, 3550 Terrace Street, S867 Scaife Hall, Pittsburgh, PA 15261, Ph: (412) 647 – 0996, Fax: (412) 648 – 8455, E-mail: cjc76{at}pitt.edu
  1. Noted as contributing equally

Abstract

Thirty-seven carbapenem-resistant Enterobacteriaceae (CRE)-infected patients were treated with ceftazidime-avibactam. Clinical success and survival rates at 30-days were 59% (22/37) and 76% (28/37), respectively. In 23% (5/22) of clinical successes, CRE infections recurred within 90-days. Microbiologic failure rate was 27% (10/37). Ceftazidime-avibactam resistance was detected in 30% (3/10) of microbiologic failures.

10.1093/cid/ciw639
UNCORRECTED PROOF

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