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Do We Need More Than 6 Weeks of Antimicrobial Treatment for Vertebral Osteomyelitis?

  1. Aurélien Dinh4
  1. 1Infectious Diseases Unit, University Hospital Bretonneau, Tours
  2. 2Clinical Research Unit, University Hospital Ambroise Paré, Boulogne
  3. 3Pharmacy Department
  4. 4Infectious Diseases Unit, University Hospital Raymond Poincaré, Garches, France
  1. Correspondence: A. Dinh, Infectious Diseases Department, 104 Bd R. Poincaré, University Hospital R. Poincaré, Versailles Saint Quentin University, Garches 92380, France (aurelien.dinh{at}aphp.fr).

To the Editor—We have read with great interest the study of Park et al [1]. They studied a retrospective cohort of 314 patients with hematogenous vertebral osteomyelitis (VO) with microbiological identification, and determined risk factors for recurrence from multivariable analysis: methicillin-resistant Staphylococcus aureus (MRSA) infection, undrained paravertebral abscess, and end-stage renal disease. Then, they evaluated recurrence rates among patients with or without risk factor(s) according to antimicrobial treatment duration. Treatment durations were not randomized and were left to the discretion of physicians. Recurrence was defined as clinical recurrence or microbiological recurrence when the same causative bacteria were identified.

They concluded that a longer treatment duration (6–8 weeks or more) …

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